Authors : Cheung KAK , Peiris H , Wallace G , Holland OJ , Mitchell MD
PMID : 31810321 PMCID : PMC6929011 DOI : 10.3390/IJMS202376079

What is Epilepsy?

Epilepsy is a neurological disorder that affects approximately 50 million people worldwide. Common symptoms of Epilepsy are

  • Uncontrollable jerking and shaking called a “fit”
  • Losing awareness and staring blankly into space.
  • Becoming stiff & unconscious.

Is there any cure for Epilepsy?

No, there is currently no definitive epilepsy cure, However in recent years medicinal cannabis (hemp-based compounds ) has been successfully trialed as an effective treatment for managing epileptic symptoms, but whose mechanisms of action are largely unknown.

What causes Epilepsy? 

Lately, there has been a focus on neuroinflammation ( inflammation of the brain or spinal cord ) as an important factor in the pathology of many epileptic disorders. While links are identified between Epilepsy, Neuroinflammation, the Endocannabinoid System ( ECS ), and how cannabinoids may be potent alternatives to common medical approaches.

We are studying the role of ECS in Neuroinflammation, and its cure using Cannabinoids ( CBS ) to potentially reduce the occurrence and severity of seizures.

Are there any fruitful results of this research? 


Cannabinoid cannabidiol ( CBD ) has been reported to have anticonvulsant ( to cop with rigidity and uncontrolled muscle spasms ) and anti-inflammatory properties, and it shows effectiveness for epilepsy treatment.

How do Cannabinoids affect Endocannabinoid System and Epilepsy? 

There is a multitude of grating pathways that involve endocannabinoids, eicosanoids, and associated receptors by which cannabinoids could potentially exert their Therapeutic effects. Further research is needed to better characterize these pathways, and consequently improve the application and regulation of medicinal cannabis

The Interplay between the Endocannabinoid System , Epilepsy and Cannabinoids