Cannabis sativa or hemp has become significantly well-known due to the therapeutic compounds found in the plant. The discoveries of Cannabidiol or CBD, cannabigerol or CBG, and Tetrahydrocannabinol or THC were a few years apart. Still, research on CBG is lacking due to its low percentage in the plant. However, researchers are now recognizing CBG for its numerous therapeutic effects.
For years, the market’s been booming with the use of CBD for inflammation. Recent research is altering the trend and making CBG derivatives more recognized.
Please keep reading to find out how effective CBG anti-inflammatory is and the effects of CBG and its derivatives on obesity.
What Are CBG and Its Derivatives?
Cannabigerol (CBG) is a compound found in hemp plants. The minor cannabinoid is non-psychoactive as it doesn’t take its consumer in a state of ‘high.’ The combination has become a significant player in the health and wellness market. Now, the availability of the mixture in the plant has caused a late boom in the compound’s demand.
HUM-223, HUM-233, and HUM-234 are widely known as CBG synthetic derivatives. The latest research proves these derivatives to be more effective against inflammation than CBG or CBD. One of the derivatives also shows significant effects on reducing obesity.
How Are the Derivatives of CBG Anti-Inflammatory?
Researchers conducted a study on the effects of the three synthetic derivatives of CBG using mice on a high-fat diet. Researchers also compared the impact of the derivatives to the effects of CBG on the guinea pigs. Here are some of the significant results that researchers found during the study.
HUM-233 and HUM-234 showed promising results that have led the researchers to believe in these CBG derivatives’ role in reducing inflammation. The compounds worked well on the mice and decreased the pain and swelling caused due to inflammation. Compared to its parent molecule CBG, HUM-233 and HUM-234 significantly outperformed the compound.
Even though HUM-233 and HUM-234 showed significant anti-inflammatory signs, the increase in the amounts of the compound showed an opposite result. Instead of curbing inflammation, high doses of HUM-233 and HUM-234 contributed to worsening the condition.
CBG, as compared to HUM-223, showed better performance. However, CBG’s anti-inflammatory activity wasn’t as promising as its derivatives. In another study conducted on mice regarding the effects of CBD or CBG and the two cannabinoids combined, the combination showed a noticeable reduction in inflammation.
HUM-223 was the least effective derivative and failed to show noticeable results in controlling or decreasing the inflammation or the swelling and pain caused by the issue.
Inflammation and Other Related Diseases
Inflammation itself is the body’s natural healing process. The white blood cells in our body produce chemicals to fight the invaders such as viruses or bacteria. Actual issues occur when the inflammatory cells overstay their visit, and the condition turns into a chronic disease.
Inflammation manifests as redness, pain, swelling, and often heat production in the area where inflammatory cells perform their job. The condition is also a contributor or symptom of numerous diseases such as arthritis, gastrointestinal disorders, and obesity. The promising effects of the CBG anti-inflammatory and its derivatives can help reduce or control the condition of inflammation and fight off numerous other diseases associated with the situation.
Regardless of the research, the use of CBD for inflammation reduction will continue due to its effectiveness. CBD or CBG oils combined may also keep trending in the market.
How Can CBG Derivatives Reduce Obesity?
HUM-233 and HUM-234 performed incredibly well in fighting the inflammatory cells that have become accomplices of numerous pathogens by exacerbating the disease. And since inflammation is one of the contributing factors to obesity, the performance of HUM-233 and HUM-234 is also promising in significantly reducing obesity. However, HUM-234 alone outperformed all the other derivatives and showed prominent effects on obesity.
Researchers tested female mice on a high-fat diet against female mice on a standard feed to study the effects of CBG and HUM-234. The research proved to show two prominent trends:
CBG fed to standard fed mice didn’t reduce or limit the process of gaining weight for the rodents. Instead, CBG had the opposite effect on the guinea pigs. The compound increased the importance of the standard-fed mice, higher than the high-fat diet mice.
In contrast, HUM-234 surprised and piqued the interest of researchers with its results. The compound significantly reduced the obesity researchers induced in rodents through a high-fat diet. This effect has led the researchers to find different arrays of studies.
Obesity is one of the most prevalent disorders all around the globe. The issue is more prominent in the youth than the elderly leading to numerous other psychological and physiological disorders. Besides, people with obesity are prone to significant health issues such as cancer, hypertension, and cardiovascular diseases.
The promising results shown by the activity of HUM-234 have given researchers hope to find a way to curb the disease and make a notable difference in the health of millions suffering from obesity.
The market had welcomed the trend of CBD for inflammation with open arms. The compound’s significant effect on the condition also increased the market’s growth. However, the latest research on the CBG anti-inflammatory has led to promising results that could change the trend of CBD for inflammation.
CBG itself failed to outperform CBD. However, in a separate study, broad-spectrum oils, made with non-psychoactive cannabinoids, proved beneficial in dealing with inflammation and curbing its effects. CBG derivatives have outperformed the combinations of CBD or CBG, and researchers are working on further studying the activity of CBG anti-inflammatory.
Where HUM-223 didn’t perform too well, HUM-233 and HUM-234 were significant players in reducing inflammation when the dosage was limited. The excess amount of compound reversed the effect.
Researchers found HUM-234 particularly promising thanks to its effects on reducing diet-induced obesity. The compound outperformed CBG, which had contributed to exacerbating obesity in standard-fed guinea pigs.
While the amount of research is limited, CBG derivatives have shown superior results and can become the new anti-inflammatory and anti-obesity drugs on the market.