Authors : Avila C . Massick S . Kaffenberger BH , Kwatra SG , Bechtel M.

Background : 

Medical marijuana is becoming widely available to patients in the U.S. and with recreational marijuana now legalized in many states, patient interest is on the rise.

The endocannabinoid system plays an important role in skin homeostasis ( regulation of fluids and temperature ) in addition to broader effects on neurogenic responses( from the nervous system, Brain / Spinal cord ) such as pruritus ( itching ) and nociception ( responding to potential damage or injury ), inflammation, and immune reactions.

CBD for the cure of Pruritus :

CBD has an anti-inflammatory property, There are numerous studies of in vitro and animal models that provide insight into the possible mechanisms of cannabinoid effects on pruritus, with the most evidence for affecting neurons, itch fibers, and cannabinoid receptors.

In addition, human studies, while limited due to differences in cannabinoids used, disease models, and delivery methods, have consistently shown significant reductions in both scratching and symptomatology in chronic pruritus.

Clinical Evidence for CBD’s as cure of Dermatologic Diseases 

Clinical studies have shown a reduction in pruritus in several dermatologic ( atopic dermatitis, psoriasis asteatotic eczema, prurigo nodularis, allergic contact dermatitis ) and systemic ( uremic pruritus, cholestatic pruritus ) diseases.

Results 

These preliminary human studies warrant controlled trials to confirm the benefit of cannabinoids for the treatment of pruritus and to standardize treatment regimens and indications.

In patients who have refractory chronic pruritus after standard therapies, cannabinoid formulations may be considered as adjuvant therapy where it is legal.