Cannabinoids  working mechanisms  and Potential Applicability to Skin Diseases 

Authors: Clinton A ‘, Lara Corrales, Pope E

 Here is what you should know : 

Legalization of Cannabis : 

The legalization of cannabis in a growing number of jurisdictions has led to increasing interest in its potential therapeutic effects in a range of disorders, including cutaneous (Skin related ) conditions.

History : 

Cannabinoids have been used as natural medicines for centuries; however, their biological activity in the skin is a new area of study.

Recent data suggest that cannabinoids are involved in neuro – Immuno – endocrine modulation of skin functioning, yet their effect on the features of dermatologic conditions is unclear.

Researches : 

We will learn the basic mechanisms by which cannabinoids regulate skin functioning for the treatment of dermatologic diseases looking at the effects of cannabinoids on a range of cellular activities and dermatologic conditions both in vitro ( cellular ) and in vivo ( Organism ) levels.

We identified studies demonstrating an inhibitory effect of cannabinoids on skin inflammation, proliferation ( tumor ), fibrosis, pain, and itching, and biological mechanisms involved in the pathogenesis of many dermatologic conditions.

Conclusion : 

Cannabinoids have the potential to expand the therapeutic repertoire of a wide spectrum of skin disorders.

Given their widespread unregulated use by the general public, basic and clinical studies are required to elucidate the effectiveness and long-term effects of topical and systemic cannabinoids in cutaneous disorders.